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Pharmaceutical Intermediate 10-Hydroxycamptothecin CAS 19685-09-7 for Topotecan Hydrochloride

Place of Origin China
Brand Name N/A
Certification COA
Model Number 19685-09-7
Minimum Order Quantity 100g/1kg
Price USD1000~10000
Packaging Details 1kg/5kg/25kg
Delivery Time 3-5 days
Payment Terms L/C, T/T, Western Union, D/A, D/P, MoneyGram
Supply Ability 100kg per month

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Product Details
Appearance Light Yellow Crystal Powder Purity (HPLC) ≥99.0%
Solubility Insoluble In Water Impurities ≤0.5%
Single Impurity ≤0.1% Loss On Drying ≤5.0%
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CAS 19685-09-7


Pharmaceutical Intermediate 10-Hydroxycamptothecin


CAS 19685-09-7 10-Hydroxycamptothecin

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Product Description

Product name:10-hydroxycamptothecin
CAS No.:19685-09-7



7-ethyl-10-hydroxycamptothecin, light yellow solid at room temperature and pressure, insoluble in water and soluble in strong polar solvents such as methanol, ethanol, DMSO and other organic solvents. 7-ethyl-10-hydroxycamptothecin, a derivative of the plant-based chemotherapeutic drug camptothecin, has extremely high antitumor activity, however, its low solubility, instability at higher pH, p-glycoprotein effection, and severe first-pass effects make its oral bioavailability extremely low. In addition, the compound can also be used in basic biochemical research, including the identification of active molecules, pharmacological experiments, activity screening, etc.

Pharmaceutical Intermediate 10-Hydroxycamptothecin CAS 19685-09-7 for Topotecan Hydrochloride 0



7-ethyl-10-hydroxycamptothecin is a derivative of camptothecin, which is a cytotoxic alkaloid of pyrroloquinoline. Besides paclitaxel, it is one of the most studied natural anti-tumor drugs. It mainly exists in the fruit or root bark of Camptothecin, a unique plant in the Chinese davirate family. As an active metabolite of topoisomerase I inhibitor irinotecan, 7-ethyl-10-hydroxycamptothecin inhibits DNA synthesis and RNA synthesis with IC50 of 0.077 and 1.3 μM, respectively. 7-ethyl-10-hydroxycamptothecin is a kind of camptothecin molecule with broad-spectrum antitumor activity, but it is difficult to transform in clinic due to solubility problems. Its water-soluble small molecule prodrug irinotecan (CPT-11) has been approved for the treatment of a variety of malignant tumors including colorectal cancer, lung cancer and ovarian cancer.


Pharmaceutical Intermediate 10-Hydroxycamptothecin CAS 19685-09-7 for Topotecan Hydrochloride 1