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CAS 51805-45-9 TCEP HCL Tris(2-Carboxyethyl) Phosphine Hydrochloride
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xPurity | ≥95% | MF | C9H16ClO6P |
---|---|---|---|
MW | 286.65 | CAS | 51805-45-9 |
Appearance | Yellow Solid | Application | Reagent |
Highlight | CAS 51805-45-9 TCEP HCL,Tris(2-Carboxyethyl) Phosphine Hydrochloride,CAS 51805-45-9 |
TCEP HCL Tris(2-carboxyethyl) phosphine Hydrochloride CAS 51805-45-9 Pharmaceuticals Raw Materials
Specification
CAS | 51805-45-9 |
Purity | ≥95% |
MF | C9H16ClO6P |
MW | 286.65 |
Appearance | yellow solid |
Application | Reagent |
Description
TCEP HCl (51805-45-9) is a reagent for selective reduction of disulfides in aqueous solutions1-3?with distinct advantages over DTT which are application specific3. For example, spin labels are more stable with TCEP than DTT, Ni2+?(leached from affinity columns) causes rapid oxidation of DTT with no effect on TCEP and for long term storage of proteins TCEP is more stable than DTT with no metal chelator (EGTA) present but DTT is more stable in the presence of metal chelators.3
TCEP (Tris(2-carboxyethyl)phosphine hydrochloride) is an alternative which is not pungent, more stable and works even at low pH. It is more selective, i.e. do not reduce metals and buried disulfides.
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