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Deoxyarbutin CAS 53936-56-4 Cosmetic Raw Materials White Powder
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|M. F.||C11H14O3||M. W.||194.23|
|Appearance||White Powder||Application||Cosmetic Raw Materials|
White Powder Deoxyarbutin For Skin,
CAS 53936-56-4 Cosmetic Raw Materials,
Deoxyarbutin Cosmetic Raw Materials
Deoxyarbutin CAS 53936-56-4 Cosmetic Raw Materials Purity ≥99.0%
|Application||Cosmetic Raw Materials|
Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.
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