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Dihexa Food Nutritional Supplement CAS 1401708-83-5 White Solid
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|CAS||1401708-83-5||Application||Food Nutritional Supplement|
Dihexa Food Nutritional Supplement,
CAS 1401708-83-5 Food Nutritional Supplement,
CAS 1401708-83-5 Dihexa Powder
Dihexa CAS 1401708-83-5 White Solid Food Nutritional Supplement
|Application||Food Nutritional Supplement|
Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.
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