A. ACTIVE INGREDIENT OVERVIEW
Chemical Name: 1-Methylcyclopropene
Molecular Formula: C4H6
Chemical Family: Methylcyclopropene
Trade and Other Names: 1-MCP
CAS Registry Number: 3100-04-7
OPP Chemical Code: 224459
B. USE PROFILE
The following, is information on the proposed uses with an overview of use sites and application
Type of Pesticide: Plant Growth Regulator
Use Sites: Enclosed indoor use on fresh cut flowers and potted flowering, bedding, nursery
foliage plants, and fruits and vegetables. Plants are treated in enclosed areas such as rooms, coolers,
greenhouses, truck trailers and shipping boxes/containers, and fruits storage areas.
Target: Inhibit the effect of Ethylene
Formulation Types: Powder
Timing: Application should be made just prior to harvest, immediately after harvest, prior to
shipment, upon arrival from the supplier, and/or just prior to sale. Repeat at weekly intervals.
C. DATA REQUIREMENTS
The mammalian toxicology and ecological effects data requirements for 1-MCP have been fulfilled.
Product analysis data requirements are adequately satisfied. The data requirements for granting this
registration under Section 3(c)(5) of FIFRA have been reviewed by the Biopesticides and Pollution
Prevention Division (BPPD). Based on submitted information, the Agency foresees no unreasonable
adverse effects to human health and the environment from the use of this chemical and recommends an
unconditional registration of this new active ingredient for the proposed uses.
D. REGULATORY HISTORY
On September 27, 1997, the Agency received an application from Biotechnologies for Horticulture, Inc.
to register EthylBolc? containing 0.43% of 1-methylcyclopropene as a plant growth regulator.
A notice of receipt of the application for registration of 1-methylcyclopropene as a new active ingredient
was published in the Federal Register on March 10, 1999 (64 FR 11868) with a 30-day comment period.
No comments were received as a result of this publication.
The Biochemical Classification Committee determined that the 1-MCP gas has not been shown to occur
naturally, and can not be proved to fit the biochemical pesticide definition. However, the low use rates
of 1-MCP and its non-persistence and non-toxic mode of action, make this plant growth regulator
eligible for a reduced data set similar to that used for biochemical pesticides applied to non-food crops in
F. FOOD CLEARANCES/TOLERANCES
In April, 2000, the Agency received a petition from AgroFresh Inc., proposing the establishment of an
exemption from the requirement of regulations for residues of the biochemical 1-MCP in or on all food
commodities. A notice of filling was published in the Federal Register of June 21, 2000 (65 FR 38550).
The final rule establishing an exemption from the requirement of a tolerance for residues of 1-
Methylcyclopropene in or on fruits and vegetables when used as a post harvest plant growth
regulator, for the purpose of inhibiting the effects of ethylene, was approved and published in the
Federal Register on July 26, 2002 (67 FR 48796).
Post time: Sep-29-2018